Neurosurgery CPT Codes: Complete Guide for Accurate Medical Billing
February 17, 2026

Neurosurgery CPT codes are five-digit numeric codes that identify specific neurosurgical procedures for billing and reimbursement. These codes, established by the American Medical Association (AMA), enable healthcare providers to document brain surgeries, spinal procedures, and peripheral nerve operations for insurance claims. The Current Procedural Terminology (CPT) system includes over 200 codes specific to neurosurgical interventions.
Neurosurgery CPT codes fall into 5 primary categories:
Each category contains specific code ranges that correspond to anatomical locations and surgical techniques.
Cranial surgery codes document procedures involving the skull and brain. Common codes include:
These codes require documentation of tumor type, surgical approach, and anatomical location.
Spinal surgery codes identify procedures on the vertebral column and spinal cord. Key codes include:
Proper coding requires specification of spinal levels, surgical approach (anterior or posterior), and the number of segments treated.
Peripheral nerve codes document operations on nerves outside the brain and spinal cord. Common procedures include:
These codes require identification of specific nerves, such as the median, ulnar, radial, or sciatic.
Approximately 200–250 CPT codes are associated with neurosurgical procedures. This number includes
The AMA updates these codes annually to reflect advances in surgical technology and techniques.
Brain tumor surgery codes vary based on tumor location and approach. The 8 most frequently used codes include:
Documentation must specify tumor histology, size, and exact anatomical location for proper code selection.
Spinal fusion procedures utilize 4 main code categories based on surgical approach:
| Approach Type | CPT Code Range | Common Procedures |
| Anterior Cervical | 22548-22554 | ACDF, corpectomy with fusion |
| Posterior Lumbar | 22612-22614 | Posterolateral fusion, TLIF |
| Anterior Lumbar | 22558-22585 | ALIF, lateral interbody fusion |
| Combined Approach | 22630-22634 | 360-degree fusion, PLIF |
Selection depends on surgical technique, levels fused, and instrumentation used.
Minimally invasive spine surgery (MISS) uses the same CPT codes as open procedures. Code selection depends on the procedure performed, not the surgical approach. Add modifier -22 to indicate increased procedural complexity, if documented. According to the North American Spine Society (NASS), proper documentation of endoscopic or percutaneous techniques supports the use of this modifier.
Stereotactic procedures use image guidance for precise targeting. Primary codes include:
These codes apply to Gamma Knife, CyberKnife, and linear accelerator-based treatments.
Vascular neurosurgery codes address aneurysms, arteriovenous malformations (AVMs), and cerebrovascular disorders. Key codes include:
Documentation must specify aneurysm size, location (anterior versus posterior circulation), and complexity factors.
Modifiers alter CPT code meanings to reflect specific circumstances. 6 essential modifiers for neurosurgery include:
Modifier 22 requires documentation explaining why the procedure exceeded typical complexity. Research from the American Association of Neurological Surgeons (AANS) indicates that proper modifier use increases reimbursement accuracy by 38%.
Accurate coding requires 5 documentation elements:
Theoperative report must describe the surgical approach, structures addressed, complications encountered, and time spent on each procedure component.
The AMA updates CPT codes annually on January 1st. Changes include new codes for emerging procedures, deleted codes for obsolete techniques, and revised descriptors for existing codes. Neurosurgery receives approximately 8-12 code updates each year. Providers must review the CPT codebook updates and implement changes immediately to maintain billing accuracy.
Revision procedures use specific CPT codes when available or add modifier -78 to the original procedure code. Revision spine surgery codes include:
Documentation must clearly state that the procedure is a revision and explain the reasons for reoperation.
Medical necessity justifies why a procedure is required. Documentation must demonstrate 4 key elements: symptoms requiring intervention, conservative treatments attempted without success, clinical findings supporting surgery, and expected functional improvement. CMS reviews medical necessity to determine coverage eligibility and appropriate reimbursement levels.
Accurate neurosurgery coding requires specialized knowledge of complex procedures, anatomical variations, and evolving CPT guidelines.
Oregon Billing Service specializes in neurosurgery medical billing, ensuring precise code selection, proper modifier application, and comprehensive documentation review.
Our certified coding specialists stay current with annual CPT updates, NCCI edits, and payer-specific requirements. Contact Oregon Billing Service today to optimize your neurosurgery revenue cycle management and eliminate costly coding errors.
Q1. What is CPTcodese 99401 and 99404?
Ans. CPT codes 99401 – 99404 are designated to report services provided to individuals at a face-to-face encounter for the purpose of promoting health and preventing illness or injury.
Q2. What is the difference between CPT code 81001 and 81002?
Ans. The main difference between CPT codes 81001 and 81002 lies in the method of analysis (automated vs. non-automated).
Q3. What is the ICD 10 code for a history of cranial surgery?
Ans. ICD-10 Coding for History of Craniotomy(Z98. 890, Z48. 811, G97. 82)